Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (15): 2455-2460.doi: 10.3969/j.issn.2095-4344.2014.15.026

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A meta-analysis of mud therapy on knee osteoarthritis pain

Deng Zhen-han, Yang Tuo, Li Hui, Zhang Yi, Li Yu-sheng, Lei Guang-hua   

  1. Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
  • Online:2014-04-09 Published:2014-04-09
  • Contact: Lei Guang-hua, M.D., Professor, Chief physician, Doctoral supervisor, Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
  • About author:Deng Zhen-han, Studying for master’s degree, Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China

Abstract:

BACKGROUND: As a therapy means of osteoarthritis, mud therapy has attracted great attention from the researchers, but its effectiveness still remains controversial in the previous studies.
OBJECTIVE: To analyze the effectiveness of mud therapy for relieving knee osteoarthritis pain.
METHODS: An online search through Pubmed/Medline database was performed, and the relevant literatures were manually retrieved. The retrieval deadline was set on March 9, 2013. Randomized controlled trials and prospective controlled trials addressing mud therapy of knee osteoarthritis were collected.
RESULTS AND CONCLUSION: A total of seven studies of meta-analysis involving 410 cases were included. There was a significant difference between treatment group and control group in the visual analogue scale pain score (standardized mean difference: -0.74) and WOMAC pain score (standardized standard deviation: -0.30). Mud therapy can attenuate knee osteoarthritis pain. But this conclusion needs to be confirmed by more high-quality randomized controlled trials.



中国组织工程研究
杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松组织工程


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Key words: osteoarthritis, knee, pain, mud therapy, evidence-based medicine

CLC Number: